PHYSOSTIGMINE SALICYLATE SALT
Eserine Salicylate
CAS: 57-64-7
Molecular Formula: C22H27N3O5
PHYSOSTIGMINE SALICYLATE SALT - Names and Identifiers
PHYSOSTIGMINE SALICYLATE SALT - Physico-chemical Properties
| Molecular Formula | C22H27N3O5 |
| Molar Mass | 413.47 |
| Melting Point | 181-183°C |
| Appearance | neat |
| Merck | 7384 |
| BRN | 3900576 |
| pKa | pKa 1.96/8.08(H2O,t =15) (Uncertain) |
| Storage Condition | 2-8℃ |
| MDL | MFCD00135659 |
PHYSOSTIGMINE SALICYLATE SALT - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | 26/28 - Very toxic by inhalation and if swallowed. |
| Safety Description | S25 - Avoid contact with eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1544 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | TJ2450000 |
| HS Code | 2939800000 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
| Toxicity | LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch) |
PHYSOSTIGMINE SALICYLATE SALT - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | Physostigmine salicylate (ethine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicyl can penetrate the blood-brain barrier and stimulate central cholinergic neurotransmission. Physostigmine salicyl can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic intoxication. |
| Animal Model: | Heterozygous transgenic mice (Tg(+) mice) |
| Dosage: | 0.03, 0.1, and 0.3 mg/kg |
| Administration: | SC; daily for 6 weeks |
| Result: | Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals. |
| Use | is an ophthalmic medication for the treatment of primary angle-closure glaucoma, occasionally primary open-angle glaucoma. |
Last Update：2024-04-09 21:01:54
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